Study Reveals What Long-Term Fasting Really Does to The Human Body

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In recent years, water-only fasting has surged in popularity, often showcased across social media as a shortcut to health and wellness. However, beneath the glossy posts and anecdotal testimonials, scientists are urging caution. A new international study has taken a close look at what really happens to the body during an extended period of consuming nothing but water, and the results are both illuminating and sobering.

The Study: Ten Days With Only Water

A group of researchers from multiple countries recruited 20 adult participants willing to undertake a challenging regimen: ten days of water-only fasting. This meant no food, no juices, no teas—just water, and plenty of medical supervision. The volunteers were monitored closely throughout the experiment, with their health markers and experiences meticulously recorded.

Weight Loss: Swift but Not Always Sustainable

One of the most striking outcomes was weight loss. On average, participants shed about 7.7 percent of their body weight over the ten-day period. This rapid drop is consistent with previous findings, where water-only fasting led to noticeable reductions in body mass, abdominal circumference, and body mass index (BMI). However, the nature of this weight loss is crucial to understand.

Much of the initial weight lost during water fasting comes from water, glycogen stores, and some lean muscle, not just fat. While the reduction in abdominal circumference suggests a decrease in visceral fat—a type associated with metabolic issues—there is also a risk of losing muscle mass and essential fluids.

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Side Effects: More Than Just Hunger Pangs

While the idea of a “reset” may be appealing, the reality of water fasting is far from glamorous. Participants reported a range of side effects, including:

  • Headaches
  • Insomnia
  • Fatigue
  • Dizziness
  • Dry mouth
  • Low blood pressure

These symptoms are well-documented in fasting literature and are often the body’s response to a sudden lack of nutrients and electrolytes. Notably, dehydration is a real risk during water-only fasting, as a significant portion of daily fluid intake typically comes from food. Without this, even drinking water may not be enough to maintain proper hydration.

Blood Pressure and Heart Health: A Double-Edged Sword

Blood pressure tends to drop during water fasting, which can be beneficial for some but dangerous for others. Individuals with pre-existing cardiovascular conditions are particularly vulnerable, as the added strain and sudden changes can exacerbate underlying issues. Orthostatic hypotension—a sharp drop in blood pressure upon standing—was also observed, increasing the risk of dizziness and fainting].

Inflammation: Not the Expected Outcome

A key hypothesis driving this research was the belief that extended water fasting would reduce inflammation in the body. Inflammation, after all, is a root cause of many chronic diseases. Surprisingly, the study found the opposite: markers of inflammation actually increased during the fasting period.

Researchers measured levels of specific proteins in the blood, such as C-reactive protein (CRP) and interleukin-8 (IL8), both associated with the body’s inflammatory response. These proteins were found to be significantly elevated, suggesting that prolonged fasting may, in fact, put the body under stress and trigger an inflammatory reaction.

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Metabolic Changes: Insulin Sensitivity and Beyond

Despite the concerns, there were some positive shifts in metabolic health. Prolonged water-only fasting led to improved markers of insulin sensitivity and reductions in glucose and leptin levels. These changes are promising for those at risk of metabolic syndrome or insulin resistance, but the sustainability of these benefits remains uncertain, especially once normal eating resumes.

The Refeeding Phase: A Critical Transition

After the fasting period, participants were gradually reintroduced to food, typically starting with whole-plant foods without added salt, oil, or sugar. This refeeding phase is essential, as improper reintroduction of food can lead to dangerous complications, including refeeding syndrome—a potentially life-threatening shift in fluids and electrolytes.

Interestingly, hunger levels often surged after the fasting period, making it challenging for participants to maintain their weight loss. If not carefully managed, this rebound hunger can lead to rapid weight regain, undermining the potential metabolic benefits achieved during the fast.

Safety and Supervision: Not a DIY Approach

The consensus among researchers is clear: prolonged water-only fasting should never be attempted without medical supervision. While the studies reviewed did not report any serious adverse events or deaths, mild symptoms were common, and the risks for certain populations—such as those with heart disease, metabolic disorders, or a history of eating disorders—are significant.

Potential Benefits: More Than Just Weight Loss?

Some research suggests that fasting, when done intermittently or for shorter durations, may offer benefits beyond weight loss. For example, studies in animal models have shown that intermittent fasting can reduce amyloid deposits in the brain and improve cognitive function, hinting at a possible role in protecting against neurodegenerative diseases. However, these findings do not necessarily translate to the effects of long-term, water-only fasting in humans.

Electrolytes and Nutrient Balance: A Delicate Equation

Extended periods without food can disrupt the balance of electrolytes in the body, particularly sodium and chloride, which were observed to decrease just below acceptable limits after 8–10 days of fasting. This underscores the importance of monitoring and, if necessary, supplementing electrolytes during prolonged fasts to prevent complications.

Hormonal Shifts: Thyroid and Longevity Links

Fasting also affects hormone levels. Notably, thyroid hormones such as triiodothyronine (T3) and thyroid-stimulating hormone (TSH) decreased during the fasting period. Interestingly, lower T3 levels—when not accompanied by impaired thyroid function—are associated with increased longevity in some studies. However, the long-term implications of these hormonal changes remain unclear.

Who Should Avoid Water-Only Fasting?

Certain groups should steer clear of extended water fasting unless under strict medical guidance. These include:

  • Individuals with gout, as fasting can increase uric acid and trigger attacks
  • Those with a history of eating disorders, due to the risk of disordered eating behaviors
  • People with chronic illnesses such as diabetes, cancer, or cardiovascular disease

Social Media Hype vs. Scientific Reality

While water-only fasting may be trending online as a quick fix for weight loss or detoxification, the science paints a more nuanced picture. The allure of dramatic results must be weighed against the real risks and the lack of long-term data on safety and efficacy.

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Final Thoughts: Proceed With Caution

The findings from this international study offer a comprehensive look at what happens to the human body during a ten-day water-only fast. The process can lead to rapid weight loss and improvements in some metabolic markers, but it also brings a host of side effects, potential dangers, and an unexpected increase in inflammation for some participants.

For those considering water-only fasting, the message from researchers is unequivocal: consult a healthcare professional and never attempt such a regimen without expert supervision. The journey to better health is rarely as simple as skipping meals, and the body’s response to extreme fasting is complex, unpredictable, and, in some cases, risky.

In summary: Water-only fasting is not a one-size-fits-all solution. While it may offer certain benefits under the right conditions, it is accompanied by significant challenges and potential hazards. A balanced, evidence-based approach to nutrition and health remains the safest path forward.

Sarah Avi
Sarah Avi

Sarah Avi is one of the authors behind FreeJupiter.com, where science, news, and the wonderfully weird converge. Combining cosmic curiosity with a playful approach, she demystifies the universe while guiding readers through the latest tech trends and space mysteries.

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